Histochemical study of asbestos fibre coating in experimental carrageenin granulomas.

A histochemical study of the asbestos body coating.

LECTIN HISTOCHEMISTRY OF CHOLESTEROL CLEFT GRANULOMAS IN NON-SPECIFIC INTERSTITIAL PNEUMONIA (NSIP)

 ABSTRACT Background: Cholesterol cleft granulomas with clusters of giant cells were noted to be a common feature of non-specific interstitial pneumonia (NSIP). Objective: This study aimed to define the cell populations involved in the granulomas. Methods: The granulomas of 16 patients with cryptogenic fibrosing alveolitis (five cases with the histological features ofNSIP, five with those ofUIP...

Extreme airborne asbestos concentrations in a public building.

Fibre concentrations of asbestos were measured in the air of a communal dining room in which the damaged ceiling had a sprayed on coating of insulation containing asbestos. The average concentration of crocidolite asbestos fibres was 4 f/cm3, 20 times the highest air concentration that appears to have been reported previously for a public building. It is concluded that although air concentratio...

New insights on the biomineralisation process developing in human lungs around inhaled asbestos fibres

Once penetrated into the lungs of exposed people, asbestos induces an in vivo biomineralisation process that leads to the formation of a ferruginous coating embedding the fibres. The ensemble of the fibre and the coating is referred to as asbestos body and is believed to be responsible for the high toxicological outcome of asbestos. Lung tissue of two individuals subjected to prolonged occupati...

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study.

Carbon nanotubes have distinctive characteristics, but their needle-like fibre shape has been compared to asbestos, raising concerns that widespread use of carbon nanotubes may lead to mesothelioma, cancer of the lining of the lungs caused by exposure to asbestos. Here we show that exposing the mesothelial lining of the body cavity of mice, as a surrogate for the mesothelial lining of the chest...